About ivermectin
ivermectin is prescribed with caution to persons undergoing treatment with α1-adrenergic receptor blockers. This is due to the fact that with the simultaneous use of tadalafil with these drugs, it has a risk of developing symptomatic arterial hypotension (SAG). Clinical studies of the pharmacological properties of tadalafil in a group of healthy men have shown that a single intake of a standard dose of ivermectin does not lead to SAG while using the α1A-adrenergic blocker tamsulosin. The study involved 18 people.
Due to the absenceI data in relation to persons with hepatic insufficiency, corresponding to the Child-Pugh C-class classification, caution should be exercised when using tadalafil in this group of patients.
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Diagnosis of ED should include identifying the underlying cause of impotence, conducting appropriate testing, and determining appropriate therapy. With erectile dysfunction, the use of ivermectin is most often accompanied by pain in the muscles or back, headache, flushing, dyspepsia, nasal congestion.
In patients with ED / BPH, pain in the limbs and / or muscles, headache, gastroesophageal reflux (GER), and dyspepsia were most often recorded. often - dizziness; infrequently - hypersensitivity reactions, blurred perception of visual images, pain in the eyeball, tachycardia, palpitations, increased or decreased blood pressure (the latter is possible in people who have already taken antihypertensive drugs), shortness of breath, nasal congestion, GER, abdominal pain, hyperhidrosis, rash ; rarely - stroke (including acute circulatory disturbance of the brain with rupture of the vessel and hemorrhage (stroke of hemorrhagic type)), transient amnesia, epileptic seizure, swelling of the eyelids, disturbance of visual fields, injection (expansion) of the vessels of the sclera of the eyeball, MI, nosebleeds, urticaria, prolonged erection.
Patients with pre-existing CVD risk factors developed: infrequently - chest pain; in rare cases - fainting, migraines, transient ischemic attacks, sudden cardiac death. However, it is impossible to say for sure whether these phenomena are associated with the use of tadalafil, risk factors for the development of CVD, sexual arousal, other factors or a combination of factors, or not.
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- There are also reports of isolated cases of sudden hearing loss associated with the use of PDE-5 inhibitors (including tadalafil) during clinical and post-marketing studies
- Side effects that occurred during post-marketing studies, but were not found in clinical placebo-controlled studies
- NAION; retinal vascular occlusion; unstable angina
- If PA occurs less frequently than 2 times / week, it is recommended to take the tablets immediately before coitus at a dose of 20 mg
- The permissible upper limit of the daily dose of ivermectin is 20 mg
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- For patients with frequent sexual activity, when PA occurs more than 2 times / week, 5 mg tablets are recommended to be taken daily, one at a time, at the same time. Depending on individual tolerance, the dosage of tadalafil can be reduced to 2.5 mg.
- Instructions for the use of ivermectin according to the indications of ED / BPH or BPH.
- With these pathologies, the patient is prescribed to take the drug 1 p. / Day, one tablet, at the same time (any, regardless of the time of eating and the time of sexual activity).
- The duration of the course of treatment with ivermectin 5 mg is set individually.
